Drug Effects and Monitoring

Haemocompatibility testing of polymers by thromboelastography

18th ISTH; July 6-12; 2001: P2925
Stemberger M, Stemberger A,Calatzis A,Ibrahim K,Kohn J

Plastic Materials
Haemocompatibility

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Thrombelastography (TEG) shows more rapid clot formation and polymerisation in woman taking hormone supplements

18th ISTH; July 6-12; 2001: P1461
Hall D, Mallett S, Royston D, Thornton M

Hypercoagulation
Steroid hormons

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Effect of treatment with recombinant factor VIIa (NovoSeven) or activated prothrombin complex concentrate (Feiba) on blodd coagulation system

Thrombosis Haemostasis;2001; P601
Geisen U, Keller F, Grossmann R, Schambeck CM

rF VII a
FEIBA

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Hemostatic changes in patients receiving hydroxyethyl starch: the influence of ABO blood group

Anesth Analg. 2001 Jun; 92(6):1396-401
Huraux C, Ankri A A, Eyraud D, Sevin O, Menegaux F, Coriat P, Samama CM

AB0 blood group
HES

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Monitoring blood clot polymerisation inhibition by hydroxyethyl starch via extrinsic activated thrombelastography

Proceedings of the 16th international Congress of Clinical Chemistry, London 1996
Calatzis An., Hipp R., Mößmer G., Stemberger A.

HES
Polymerisation disorders

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The effect of the combined administration of colloids and Ringer's Lactate on the coagulation system - an in vitro study using thrombelastography (roTEG)

Critical Care, 2001, vol..5, suppl..1
Fries D., Innerhofer P., Klingler A., Berresheim U., Calatzis A., Schobersberger W.

Plasma expander
Gelatine
HES

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Emergency use of recombinant factor VIIa in life threatening haemorrhagia in patients on oral anticoagulation therapy. Monitoring of the efficacy by a novel whole blood teg principle from whichvelocity profiles of clotting can be established

34th Nordisk Coagulation Meeting, Göteborg 7-9 Juni 2001
Sorensen B, Johansen P, Sorensen JC, Ingerslev J

Oral anticoagulation
rF VIIa
Novo Seven®

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Emergency use of NovoSeven in life-Threating haemorrhagia in patients on oral anticoagulation therapy: Monitorung of efficacy by a novel whole blood TEG principle from which velocity and acceleration profiles of clotting can be established 6th Novo N

Copenhagen - Denmark 3-4 May 2001
Sorensen b, Johansen P, sorensen JC, Ingerslev J

RF VIIa
Oral antcoagulation
Novo Seven®

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Coagulation effects of a recently developed hydroxyethyl starch (HES 130/0.4) compared to hydroxyethyl starches with higher molecular weight

Acta Anaesthesiol Scand. 2000; Oct;44(9):1116-21
Entholzner EK, Mielke LL, Calatzis AN, Feyh J, Hipp R, Hargasser SR

HES

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The effect of hydroxyethyl starch 200 kD on platelet function

Anesth Analg. 2000 Oct;91(4):823-7
Stogermuller B, Stark J, Willschke H, Felfernig M, Hoerauf K, Kozek-Langenecker SA

HES
HES 200
Celite modified TEG®
PFA-100®
Platelet function
GPIIb/IIIa

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Effects of unfractionated heparin, low-molecular-weight heparin, and heparinoid on thromboelastographic assay of blood coagulation

Am J Clin Pathol. 2000 May;113(5):725-31
Zmuda K, Neofotistos D, Ts'ao CH

UFH
Heparin
LMWH
Danaparoid
Heparinase

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Management and monitoring of recombinant activated factor VII

Blood Coagul Fibrinolysis. 2000; Apr;11 Suppl 1:S25-30.
Ingerslev J, Christiansen K, Calatzis A, Holm M, Sabroe Ebbesen L.

rF VII a
Novo Seven®
Haemophilia
Inhibitors

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Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists

Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1162-7
Mousa SA, Khurana S, Forsythe MS

Platelet glycoprotein IIb/IIIa antagonists binding kinetics integrins
Tissue factor

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Synergistic interactions between the low molecular weight heparin (LMWH) tinzaparin & different platelet GPIIb/IIIa antagonists: potential implication in thromboembolic disorders

Blood 2000, ASH
Mousa S., Forsythe M.

Heparin
Low-molecular-weight
Tissue factor pathway inhibitor

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Comparative efficiacy between different low molecular weight heparin (LMWH) and various molecular weight distribution fractions in inhibiting platelet-fibrin clot retraction under shear-mediated by tissue factor and endotoxin using TEG

Blood 2000, ASH
Mousa S., Forsythe M., Larnkjaer A., Johansen K.

Tissue factor
Heparin
LMWH

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Differential behavior of anti-Xa adjusted low molecular weight heparins in native whole blood analysis as performed by thromboelastography and activated clotting time

Blood 2000, ASH
Iqbal O., Hoppenstaedt D., Lewis B., Leya F., Ma Q., Fareed J.

Heparin
Low-molecular-weight
Coagulation tests

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Heparinase is capable of neutralizing the anticoagulant and hemorrhagic effects of a synthetic pentasaccharide

Blood 2000, ASH
Iqbal O., Shadid H., Silver P., Walenga J., Daud A., Ahmad S., Fareed J.

Heparinase
Pentasaccharide

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Influence of fibrinogen concentration and platelet count on extrinsic activated thrombelastography (ExTEG)

Anesth Analg 1997;84:S230
Calatzis An.,Calatzis Al.,Kling M., Entholzner E.,Stemberger A.,Hipp R.

Fibrinogen
Platelet function
Platelet count

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Monitoring of recombinant factor VIIa (NovoSeven) therapy

U. Friedrich, L. Tengborn, U. Hedner
Novo Nordisk Symposium "World Federation Haemophilia Congress", Sevilla 19-24 May, 2002

r F VIIa
Novo Seven (R)
Haemophilia

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In-vitro Effekt von c7E3-Fab und Cytochalasin D in der Thrombelastographie

Lang T., Toller W., Gütl M., Mahla E., Freisinger F., Metzler H., Halwachs-Baumann G.
Klinisches Institut f. Med. u. Chem. Labordiagnostik, LKH-Universitätsklinikum Graz, Österreich
Wiener Klin. Wschr. 2002, 114 (Suppl. 4): 124

Platelet Count
FIBTEM

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c7E3-Fab (Abciximab, ReoPro(R)) kann den Einfluss der Thrombozyten im TEG nicht vollständig eliminieren

Lang T., Toller W., Rehak P.H., Gütl M., Mahla E., Metzler H., Halwachs-Baumann G.
Klinisches Institut f. Med. u. Chem. Labordiagnostik, LKH-Universitätsklinikum Graz, Österreich
Wiener Klin. Wschr. 2002, 114 (Suppl. 4): 13

Fibrinogen
FIBTEM

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Monitoring of platelet concentrates during storage by flow cytometry, aggregometry, resonance thrombography and rotational thrombelastography

Geidel K., Brockmann M.-A., Magens M.M., Siemensen M., Duka F., Kuehnl P., Gutensohn K.
Department of Transfusion Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Infus Ther Transfus Med 2001; 28: (Sonderheft 1): 1-70

Platelet Concentrates

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c7E3-Fab (Abciximab, ReoPro®) kann den Einfluss der Thrombozyten im TEG nicht vollständig eliminieren

Lang T., Toller W., Rehak P.H., Gütl M., Mahla E., Metzler H., Halwachs-Baumann G.
Klinisches Institut f. Med. u. Chem. Labordiagnostik, LKH-Universitätsklinikum Graz, Österreich

Reo Pro
Fibrinogen

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Citrate Anticoagulation for Extracorporeal Circuits: Effects on Whole Blood Coagulation Activation and Clot Formation

Calatzis A., Toepfer M., Schramm W., Spannagl M., Schiff H.
Divisions of Hemostaseology and Nephrology, Med. Klinik Innenstadt, Ludwig Maximillians University, Munich, Germany
Nephron 2001; 89:223-236

Citrate Anticoagulation
Ecarin

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Assay Analysis on a hemophilia A patient with inhibitors under factor VIIa therapy

Friedrich U., Tengborn L., Hedner U.
Novo Nordisk A/S, Copenhagen, Denmark, Sahlgrenska Hospital, Gothenburg, Sweden

F VIIaNovo SevenHaemophiliaInhibitors

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The Influence of Intravascular Volume Therapy with a New Hydroxyethyl Starch Preparation (6% HES 130/0.4) on Coagulation in Patients Undergoing Major Abdominal Surgery

Haisch G., Boldt J., Krebs C., Kumle B., Suttner St., Schulz A.
Anesth. Analg 2001, 92: 565-71

HES

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Die Kollagen-induzierte Plättchenaktivierung im Vollblut beeinflusst die mittels Thrombelastographie bestimmte Gerinnselbildung

Krause S., Scholz Th., Temmler U., Lösche W.
Friedrich-Schiller-Universität Jena, Zentrum f. Vaskuläre Biologie und Medizin Erfurt

Platelet function
Collagen

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Whole blood coagulation thrombelastographic profiles employing minimal tissue factor activation

Sørensen B., Johansen P., Christiansen K., Woelke M., Ingerslev J.
Journal of Thrombosis and Haemostasis, Vol.1, Issue 3, 3/2003

Novo Seven
Factor VIIa
Haemophilia
Oral anticoagulation

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Potential role of the dynamic properties of whole blood coagulation in assessment of dosage requirements in haemophilia

Ingerslev J., Poulsen L. H., Sørensen B.
Haemophilia (2003), 9, 348-352

Haemophilia
F VIII
F VIII concentrates
Dosaging of F VIII concentrates
B domainless F VIII
diluted tissue factor

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